bIO-PRO Raman Probe for Bioprocess Applications

The bIO-PRO Raman Probe delivers optimal performance with each Raman analyzer in the RAMANRXN SYSTEMS suite. Utilizing a state-of-the-art design, this probe features a fixed-focus approach which provides for long-term measurement stability while also delivering a high signal-to-background measurement at any length of optical fiber. It is this novel design which allows the probe a 12mm OD, IP-65 rating, and suitability for SIP/CIP applications common to bioprocessing.

The design of these probes, complete with their industry standard 120mm length and right angle connectors, make them ideally suited for side port applications in traditional stainless steel as well as bag lined stainless steel bioreactors/fermenters. Additionally, their Pg 13.5 threading enables their use with industry standard housings for Standard, Safety, Sanitary, and NA Connect ports alike.

All bIO-PRO Raman probes utilize a single fiber for excitation and another for collection. For applications in pilot and manufacturing, this provides a robust interface and sampling versatility while reducing fiber cost over long runs. Single collection fibers also permit simultaneous multi-channel operation on a single analyzer. Standard fiber cable length is 5 meters, however cable runs of up to 400 meters are feasible options.

Probe Features
  • 12mm OD
  • 120mm Length
  • Right Angle Connection
  • SIP, CIP, or Gamma Sterilizable
  • Pg 13.5 Threaded Connector
  • One In / One Out Fiber Optics
  • Integrated "Laser On" Indicator
  • Patented Probe Design
  • Compatible with Industry Standard Housings
    for 25mm Side Ports
  • IP-65 Rated
Product Resources
Title Category Format ID#  
Raman-Based Nutrient Control in Bioprocessing Optimizes Viable Cell Density and Protein Glycation Raman Application Note PDF AN328
Raman spectroscopy for in-line, real-time fermentation monitoring PDF POST006
Raman spectroscopy technologies enabling in situ real-time bioprocess monitoring PDF POST008
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