Kaiser hosts a series of complimentary webinar presentations which demonstrate Raman Spectroscopy-based solutions. Hear from real customers and their success stories using Kaiser Raman analyzers and instruments. Examples of Research Raman, Analytical Raman, Process Raman, In Situ Raman, Industrial Raman, Remote Raman, and Raman Imaging and Microscopy are available during these sessions. We invite you to register for an upcoming webinar of interest, or view previous archives. Kaiser Webinar Archives are available in the sidebar -- see what you've been missing!
Real Customers - Their Applications, Raman Solutions
Non-invasive Raman Analysis of Pharmaceutical Tablets and Powders
Recent advances in wide area illumination methods to increase sampling volume, and thus improve representativeness of a sample, have resulted in new opportunities for Raman spectrometry in the analysis of solids. In this work, a Kaiser PhAT probe and workstation were used to acquire back-scattered and transmission Raman spectra of tablets with an active pharmaceutical ingredient (API) content of 3% w/w. The following webinar will discuss the relative merits of back-scattered and transmission Raman for the qualitative determination of the API. The effects of the particle size of excipients in the calibration tablets on the estimated API concentrations will be compared for back-scatter and transmission measurements.
A Kaiser PhAT probe was also used to obtain non-invasive back-scattered Raman spectra of powder blending. Initially, experiments were carried out on static materials to establish the information depth of the technique. The mixing of aspirin and microcrystalline cellulose in a small-scale convective blender was then monitored. The ability to study the mixing dynamics and to make quantitative measurements will be discussed, and comparisons will be made with results obtained using near infrared spectrometry.
AIR DATE: June 23, 2011
Name: Dr. David Littlejohn
Title: Professor and Associate Deputy Principal for Research
Company: University of Strathclyde
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