Kaiser hosts a series of complimentary webinar presentations which demonstrate Raman Spectroscopy-based solutions. Hear from real customers and their success stories using Kaiser Raman analyzers and instruments. Examples of Research Raman, Analytical Raman, Process Raman, In Situ Raman, Industrial Raman, Remote Raman, and Raman Imaging and Microscopy are available during these sessions. We invite you to register for an upcoming webinar of interest, or view previous archives. Kaiser Webinar Archives are available in the sidebar -- see what you've been missing!
Real Customers - Their Applications, Raman Solutions
Application of Raman Spectroscopy to Solid-state Characterization During Early Drug Development
Raman spectroscopy generally serves as a secondary technique for solid-sate characterization of pharmaceuticals in early stages of drug development. However, in certain cases this technique is of primary importance. Case studies will illustrate practical scenarios in which this technique is preferred over conventional solid-state characterization techniques, such as x-ray powder diffraction (XRPD).
Case Study 1: Raman spectroscopy was used to investigate the disproportionation of the hydrochloride salt of a free base. Due to the isostructural nature of their crystalline lattice, XRPD patterns could not be used to differentiate between the hydrochloride salt and the free base hydrate using X-ray diffraction. However the Raman spectrum of the two forms showed clear differences. This enabled in-situ monitoring by Raman spectroscopy which provided key information on the viability of the hydrochloride salt for further development.
Case Study 2: Hydrate formation for compound B in various binary mixtures of organic solvent and water was monitored in-situ using dispersive Raman spectroscopy. The data was used to identify process conditions under which the desired phase was thermodynamically stable and could be scaled up without risk of generating the undesired phase.
AIR DATE: March 11, 2010
Name: Dr. Sachin Lohani, Solid-state Characterization Expert, Merck & Company
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