Raman spectroscopy has become established in many pharmaceutical research and analytical laboratories. Applications benefiting from Raman are plentiful, and extend from screening in early phase Discovery to final product testing in Manufacturing. Due to the high-information content contained in the Raman spectrum, chemical and in some cases physical information regarding the material under investigation can be obtained.
This information can be critical to the goals of product quality and manufacturing robustness by generating process understanding. The US Food and Drug Administration (FDA) recent initiative in Process Analytical Technology (PAT) and Quality by Design (QbD) manufacturing encourages the application of tools and methodologies to ensure product quality within the pharmaceutical industry by providing a framework for quality by design.
Drug Product Applications Include:
Have an application that requires further investigation? Complete our Application Feasibility form to determine if Raman is a suitable technique.
Further information on pharmaceutical Raman applications can be found in Handbook of Raman Spectroscopy: From Laboratory to Process Line by Ian R. Lewis and Howell G. M. Edwards, Marcel Dekker, New York, New York (2001) and Pharmaceutical Applications of Raman Spectroscopy by Sobodan Sasic, John Wiley and Sons, Hoboken, New Jersey (2008)
Additional articles outlining the utility of Raman for pharmaceutical analysis and manufacturing can be found at the American Pharmaceutical Review website. www.americanpharmaceuticalreview.com
|Comparing PhAT System™ and RamanRxn1™ Approaches for the Study of Wet Granulation||Raman Application Notes||AN317|
|Following a Process-Induced Transformation During Granulation Using In Situ Techniques||Raman Application Notes||AN316|
|In-line Raman Monitoring of Protein Batch Crystallization||Raman Application Notes||AN325|
|Kinetics of a Catalytic Hydrogenation Reaction||Raman Application Notes||AN300|
|Mechanistic Study of a Microwave-Assisted Organic Reaction||Raman Application Notes||AN309|
|Monitoring a Pharmaceutical Crystal Transformation In Situ||Raman Application Notes||AN307|
|Monitoring Grignard Production in Real Time||Raman Application Notes||AN302|
|Off-Line and On-Line Raman Spectroscopy of API-Containing Extruded Films||Raman Application Notes||AN312|
|Optimizing a Microwave-Assisted Diels–Alder Reaction with Real-Time Analytics||Raman Application Notes||AN314|
|Quantifying Anhydrate/Hydrate Using Potential PAT In Situ Techniques||Raman Application Notes||AN315|
|Raman Monitoring of Active Coating Composition||Raman Application Notes||AN324|
|Raman-Based Endpoint Detection of a Heterogeneous Etherification Reaction||Raman Application Notes||AN329|
|Rapid Monitoring of Antisolvent Addition Crystallization and Dehydration||Raman Application Notes||AN308|
|Real-Time Quality Prediction of Continuously Produced Pharmaceutical Granules||Raman Application Notes||AN330|