The RamanRxn3L™ Multi-Reactor Analyzer (MRA) is a new addition to the RamanRxn Systems™ family of Raman analyzers, and is targeted to drug discovery and early process optimization customers. In these regimes, multiple parallel small-scale reactors (10-100 mL) are often used to monitor, analyze, and optimize the reaction chemistry. The ability to simultaneously follow several different potential reaction pathways can significantly speed up early process development and remove bottlenecks in the optimization pipeline. The multichannel RamanRxn3L MRA has been developed to meet and solve this need.

Raman spectroscopy provides the chemical specificity of mid-IR spectroscopy and the sampling simplicity of a near-IR analyzer. By operating in the visible spectral region, Raman spectroscopy allows vibrational spectra to be collected in situ, using fiber-coupled probe heads, without sample purging, and without the use of exotic sampling devices. The RamanRxn3L MRA utilizes fiber-coupled 1/4-inch probe optic technology for in situ reaction monitoring.

The RamanRxn Systems family of instruments is based on advanced and innovative technologies that provide distinct advantages over traditional instrumentation. The HoloPlex™ advantage, standard in all RamanRxn3L MRA systems, yields both full spectral coverage and high spectral resolution simultaneously for improved qualitative and quantitative analysis. Analysis is fast because the entire Raman spectrum is measured simultaneously, which translates into real-time data collection for reaction analysis and monitoring. The RamanRxn3L MRA uses an optional Raman Calibration Accessory (HCA) and advanced calibration protocols, developed and demonstrated in the process arena, to ensure optimal instrument performance and calibration transferability.

Why Raman?

• Fast, non-contact measurements
• Sharp spectral peaks for qualitative and quantitative analysis
• Univariate or multivariate comparative analysis methods
• Chemical specificity of mid-IR with in situ analysis
• Easy sampling of solids, liquids, slurries, and emulsions
   

Analyzer Features

• Laboratory version of the RamanRxn3 Analyzer
• Multiple sampling points
• 1/4-inch-diameter immersion optic technology
• Auto-sensoring
  self-calibrating
• Real-time data acquisition
  Applications
• Crystallization studies
• Hydrogenations
• Catalysis investigations
• Polymorphic form ID
• Emulsion polymerizations

RamanRxn3L MRA

• Monitor up to four channels with simultaneous full-spectral coverage
   
• Standard NIR laser excitation to maximize sample compatibility
   
• Available in both simultaneous or programmable sequential monitoring formats
   
• Compatible with process optics, enabling one analyzer type to be used from the discovery to the production phase
   
• Portable enclosure and fiber optic sampling interface allows the analyzer to be used in multiple locations
  

MR Probe

• Small probe construction (1/4-inch diameter, 6-inch, immersible) allows interface to standard glass reactors without an obstructive supporting gantry
   
• Uses standard reactor glass vessels
   
• Modular probe design allows the probe head to be upgraded with longer optical fibers or different immersion optics

HoloReact™ Software

• Univariate analysis tools include peak height, area, and shifts
   
• Display modes include spectrum, spectral overlay, waterfall, and reaction profile
   
• Multivariate tools include PCA and factor analysis
   
• Reaction profile and waterfall modes allow the user to quickly highlight and visualize reaction changes