RamanRxn3™ PhAT Analyzer

The RAMANRXN3 PhAT analyzer uses PhAT technology to allow quantitative monitoring and control of solid formulations during unit operations. The RAMANRXN3™ analyzer is Kaiser's process Raman analyzer solution for installations where the analyzer must be located in a hazardous area / classified environment.

The analyzer is contained in a stainless steel IP 66 enclosure, and can be supplied ATEX hazard area certified. The analyzer’s enclosure package allows the analyzer to be washed down between batches, meeting the clean-ability requirements of the pharmaceutical industry. As standard the analyzer is mounted to a trolley so it can be moved between unit operations. Alternatively, the analyzer can be mounted permanently to a wall.

Sampling versatility to various unit operations and a variety of manufacturing equipment is accomplished using a fiber-optically coupled PhAT probe head (insertion and non-contact sampling options are available). The advent of PhAT technology has opened up new areas of solid-state chemistries for Raman analysis.
 

Applications
  • Analyze Powders, Slurries, Flakes, Plaques, Gels, or Liquids
  • PAT - R&D, Primary, Secondary, or QA/QC
  • API Polymorphic Form and Stability
  • API Hydrate, Solvate, or Salt Formation
  • API Co-crystal Formation
  • Unit Operations: Blending, Granulation, Milling, and Drying
  • Process Induced Transformations During Unit Operations
  • Tablet Coating and Thickness
  • Tablet API Form, Content, and Stability
  • Low Doseage Tablets (Polymorph and Degradants)
  • Lyophilization
  • Hot-melt Extrusion
  • PAC - Polymers and Catalysts

Analyzer Features
  • Easy Sampling of Solids and Slurries
  • Representative mm Scale Measurement
  • Reproducible Sampling
  • “Focus Free” Alignment
  • Non-contact or Insertion Sampling
  • Non-destructive Measurement
  • 21 CFR Part 11 Compatible Software Option
  • IP 66 Stainless Steel Enclosure
  • Purge for Classified Environments
  • Modular Design for Easy Maintenance
  • Advanced Self Calibration Protocols

RamanRxn3™ PhAT Analyzer
Specifications:
Measurement: Raman
Laser Wavelength: 785nm
Spectral Coverage: 150-1875 cm-1 (785nm)
Environmental:
Operating Temperature: +5 to +30°C
Storage Temperature: –15 to +65°C
Relative Humidity: 20–80%, Non-condensing
(non-purged operation)
Warm-up Time: 20 Minutes
Electrical Data - Base Unit:
Input Voltage: 110-240 VAC, 50-60Hz Standard
(110-130 and 220-240 VAC
models available)
Max Power: <400 Watts Max (startup),
<220 Watts Typical
 
Physical - Base Unit:
Enclosure Type: Stainless Steel, Polymeric Seals
Mounting: Wall Mount / Trolley
Dimensions:
Wall mount

Trolley
(width × depth × height)
24" × 26" × 33"
(61 cm × 66 cm × 109 cm)
28" × 33" × 53"
(71 cm × 84 cm × 135 cm)
Weight:
(base unit alone)
260 lbs. (120 kg)
Number of Probes: Single PhAT Probe Head
Purge Package: Purge with Instrument Air
HMI: Built-in Control System Using
Windows 7, 32 Bit Professional
Certification - Base Unit:
ATEX : II 2/1 G Ex d[ia Ga][op sh Gb] px IIC T4 Gb,
Sample Interface:
Probe : PhAT Probe Head
Probe Body: Aluminum with Elastomeric O-Rings (std), or SS 316 with Kalrez O-Rings (ATEX certifiable version)

 

Product Resources
Title
Category
Format
ID#
 
PhAT Probe for Solids Analysis
Product Flyer
PDF
PF0024