PhAT System Analyzer

The PhAT SystemRaman analyzer is a variant of the RAMANRXN1™ analyzer specifically designed to address the limitations of even the best traditional Raman system for quantitative analyses of solid-state chemistries including pharmaceutical, catalysts, polymers, and specialty chemicals.

The PhAT approach to Raman sampling redefines solids sampling by eliminating sample irreproducibility and focusing, by measuring a large area of sample simultaneously, and by offering the benefits of non-destructive sampling.  Sampling versatility to various unit operations and a variety of manufacturing equipment is accomplished using a fiber-optically coupled PhAT probe head. Both insertion and non-contact sampling options are available for the PhAT probe head to enhance sampling flexibility. A special probe interface is available for in situ tablet coating applications.

The PhAT System™ Raman analyzer was designed for operations in a general purpose laboratory environment. For production in a manufacturing environment where cleanability is required for both the PhAT probe head and the analyzer, the RAMANRXN3PhAT analyzer is available.

The advent of PhAT technology has redefined the standard for simplicity and reliability for Raman spectroscopic analysis of solid samples.
 

Applications
  • Analyze Powders, Slurries, Flakes, Plaques, Gels, or Liquids
  • PAT - R&D, Primary, Secondary or QA/QC
  • API Polymorphic Form and Stability
  • API Hydrate, Solvate, or Salt Formation
  • API Co-crystal Formation
  • Unit Operations; Blending, Granulation, Milling, and Drying
  • Process Induced Transformations During Unit Operations
  • Tablet Coating and Thickness
  • Tablet API Form, Content, and Stability
  • Low Doseage Tablets (Polymorph and Degradants)
  • Lyophilization
  • Hot Melt-Extrusion
  • PAC - Polymers and Catalysts

Analyzer Features
  • Representative mm Scale Measurement
  • Reproducible Sampling
  • “Focus Free” Alignment
  • Non-contact or Insertion Sampling
  • Non-destructive Measurement
  • 21 CFR Part 11 Compatible Software Option

PhAT System Analyzer
Specifications:
Laser Wavelength: 785nm
Spectral Coverage: 150-1875 cm-1
Sample Interface:
Temperature: 20°C (Min) / 25°C (Max)
Relative Humidity: 20 to 80%, Non-condensing
Electrical Data - Base Unit:
Input Voltage: 110-240 VAC, 50-60Hz
Standard
Max Power: < 200 Watts Max (startup),
< 150 Watts Typical
User Interface: Approved PC Operating Windows7, 32-bit / 64-bit Professional (software dependent)
 
Physical Specifications - Base Unit:
Mounting: Benchtop
Dimensions: 23” x 17.63” x 8”
Weight: 61 lbs / 28 kg
Probe:
Probe Body: Aluminum with Elastomeric
O-Rings (std), SS 316 with
Buna-N or Kalrez
O-Rings (options)
Laser Power at Sample: > 150 mW
Nominal Focal Length: 3 mm lens 120 mm
4.5 mm lens 175 mm
6 mm lens 250 mm
Nominal Beam Diameter
at Focal Position:
6 mm (standard),
4.5 mm (optional),
3 mm (optional)
Weight: 2 lbs (with cable)
Length: 12"
Diameter: 1.8"
Cable Length: 3 m (std), up to 15 m (options)

 

Product Resources
Title
Category
Format
ID#
 
PhAT System
Product Flyer
PDF
PF0005
PhAT Probe for Solids Analysis
Product Flyer
PDF
PF0024