Kaiser hosts a series of complimentary webinar presentations which demonstrate Raman Spectroscopy-based solutions. Hear from real customers and their success stories using Kaiser Raman analyzers and instruments. Examples of Research Raman, Analytical Raman, Process Raman, In Situ Raman, Industrial Raman, Remote Raman, and Raman Imaging and Microscopy are available during these sessions. We invite you to register for an upcoming webinar of interest, or view previous archives. Kaiser Webinar Archives are available in the sidebar -- see what you've been missing!
Real Customers - Their Applications, Raman Solutions
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Raman Spectroscopic Fingerprint of Intermediates in Biotechnological Reactions - A Multimodal Spectroscopic Approach
The application of Process Analytical Technology (PAT) for biotechnology has several limitations including:
1. Working in an aqueous matrix with low component concentrations
2. Complex component mixtures
3. Photon scattering with changing path lengths
Due to the above limitations, highly selective and highly sensitive techniques combined with intelligent chemometric tools are required for successful biotechnology applications.
This webinar will begin with a short discussion and comparison of the spectroscopic methods with emphasis on applicability to aqueous systems with low component concentrations. Dr. Kessler will outline how to use scatter as information and not as limitation for the spectroscopic analysis of opaque systems. It will be shown that the combination of Raman spectroscopy and Multivariate Curve Resolution (MCR) provides a powerful tool to analyze complex biochemical reactions. An example will be given where the laccase-catalysed transformation of indigo carmine was studied and how intermediates can be characterized using Raman spectroscopy and MCR for underlying mechanistic interpretation.
AIR DATE: April 14, 2011
Name: Dr. Rudolf W. Kessler
Title: Professor of Chemistry
Company: Reutlingen University