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Raman Educational Webinars

Kaiser hosts a series of complimentary webinar presentations which demonstrate Raman Spectroscopy-based solutions. Hear from real customers and their success stories using Kaiser Raman analyzers and instruments. Examples of Research Raman, Analytical Raman, Process Raman, In Situ Raman, Industrial Raman, Remote Raman, and Raman Imaging and Microscopy are available during these sessions. We invite you to register for an upcoming webinar of interest, or view previous archives.  Kaiser Webinar Archives are available in the sidebar -- see what you've been missing!

Real Customers - Their Applications, Raman Solutions

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Monitoring Homogeneity Using Raman Spectroscopy in Inhalation Products

In recent years, analytical techniques that measure real-time or near real-time with high-throughput have been of great interest in the pharmaceutical industry to address the quality-by-design approach in drug development. Measuring dose uniformity for inhalation products is done by adhering to USP<601>, which requires the product to be filled into the device and performance tested, which is resource consuming.

This work, which will be presented during the webinar, demonstrates two case studies on application of Raman spectroscopy to measure homogeneity of intermediate products.
Raman spectroscopy is used to evaluate:
1) The blend uniformity of dry powder inhaler (DPI) combination product
2) Analyte homogeneity during a nasal spray manufacturing process.

First, a high throughput Raman spectroscopic method is discussed that measures the blend uniformity of two intermediate products of a DPI. This method measures uniformity of samples at the unit dose level (<5 mg) and can measure hundreds of samples in a day. Secondly, a nasal spray product is studied. The time to reach homogeneity of the analyte dispersion is evaluated with respect to surfactant concentration and surfactant type.

AIR DATE: February 17, 2011

Name: Dr. Chanda Yonzon
Title: Associate Principal Scientist
Company: Merck & Co