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The Role of Raman Microscopy in Polymorph Screening
Polymorphism is the ability of a molecule to exist in more than one crystalline form. These solid-state forms may exhibit variation in, for example, colour, stability, processability, dissolution and bioavailability, ranging from the subtle to the severe. It is for this reason that an understanding of the solid-state behaviour of a drug molecule, including the identification of all possible forms, and thorough characterisation of the observed forms is of prime importance within the pharmaceutical industry.
An in-depth understanding of the polymorph landscape of a drug candidate relies on the development and implementation of a reliable screening protocol.
During the early phases of drug development there is high attrition of drug candidates therefore screening efforts are more focussed on identifying the most stable polymorph and any process-relevant solvates or hydrates. As a drug progresses, however, attrition rates become lower and screening is more thorough, with the aim being to develop a comprehensive understanding of the polymorph landscape.
Polymorph screening at any stage requires high-throughput analysis of a large number of samples with minimal sample preparation. Thus Raman microscopy provides the ideal analytical solution.
This presentation will describe a particular case study, in which Raman microscopy was fully utilized to characterise a number of different anhydrous, hydrated and solvated forms. The study enabled selection of the most suitable solid-state form for further development as well as mitigating the risk of hydrate formation during primary and secondary processing.
AIR DATE: March 25, 2010
Name: Sarah Vallance
Title: Research Scientist, Solid Form Sciences