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Sensitivity-Enhanced Transmission Raman Spectroscopy
Transmission Raman spectroscopy can provide improved accuracy for whole pharmaceutical tablet analysis by probing a large volume of the tablet. The efficiencies for getting light into the tablet, and for collecting the Raman photons that are generated are usually poor, leading to reduced sensitivity compared to traditional backscattering measurements.
Many pharmaceutical tablets are excellent diffuse reflectors. For those tablets, transmission Raman sensitivity can be enhanced by re-directing lost photons back to the tablet surface. Some of those re-directed lost photons become Raman photons that reach the detector, thereby increasing sensitivity. Returning reflected laser photons to the tablet surface again and again effectively increases the laser power incident on the tablet. Returning uncollected Raman photons to the tablet surface effectively increases the tablet brightness, increasing the number of photons that can be collected from a given surface area and solid angle. Since the recycling of Raman photons occurs primarily via surface reflection, the sensitivity enhancement is largely unaffected by tablet self-absorption. Sensitivity enhancement factors of 40 to 60 can be achieved using this approach.
This webinar will focus on the implementation and modeling of sensitivity-enhanced transmission Raman spectroscopy for pharmaceutical tablets.
AIR DATE: October 17, 2013
Name: Dr. Michael J. Pelletier
Title: Associate Research Fellow in QbD Methods Dev Group