Kaiser hosts a series of complimentary webinar presentations which demonstrate Raman Spectroscopy-based solutions. Hear from real customers and their success stories using Kaiser Raman analyzers and instruments. Examples of Research Raman, Analytical Raman, Process Raman, In Situ Raman, Industrial Raman, Remote Raman, and Raman Imaging and Microscopy are available during these sessions. We invite you to register for an upcoming webinar of interest, or view previous archives. Kaiser Webinar Archives are available in the sidebar -- see what you've been missing!
Real Customers - Their Applications, Raman Solutions
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Single Probe Multi-purpose In Situ Monitoring and Control
At our site we have integrated two Kaiser Raman systems into the Pilot Plant scale bioreactors to investigate their performance and validate methods for measuring glucose, lactate, and other process metabolites in real time. In conjunction with a preferred vendor, an application and technology assessment was performed using a combination of published literature, process knowledge, and technical expertise. A series of candidates for assessment were identified.
At our facility the bioreactors are fitted with an aseptic automated sampling (AAS) valve to deliver offline metabolite analysis at regularly scheduled intervals throughout the duration of the batches, enabling 24 hour sampling and more than doubling the amount of comparative samples that are collected. Successful data collection and nutrient determination from the Kaiser Raman enables real time quantification of metabolites and the ability to control nutrient feeds through automated feedback loops. Additional studies to examine protein concentration in downstream processing and correlate data to in process upstream measurements are also expected.
During the webinar, I will provide a brief overview of the biologics production process, and discuss the feasibility assessment of both NIR and Raman for metabolite quantification. This includes models based on inline and offline data as well as the development of control strategies. Lastly, the development of real time protein quantification from bioreactor process samples will be discussed.
AIR DATE: June 20, 2013
Name: Tara L. Barreira
Title: Scientist, Bioprocess Research and Development