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Raman Spectroscopy


The RAMANRXN2HYBRID analyzer is the first Raman analyzer to feature both traditional small spot Raman sampling and PhAT-based wide area Raman sampling. Small spot immersion sampling remains the preferred approach for liquid-phase analysis of reaction mixtures while the added capability of PhAT-based wide area Raman sampling allows Raman analysis to be extended into the solid sampling arena eliminating sub-sampling concerns. The RAMANRXN2HYBRID analyzer uses PhAT technology to allow quantitative monitoring and control of solid formulations during unit operations.

The RAMANRXN2HYBRID fiber-coupled Raman analyzer serves the needs of the analytical Raman market, process analytics, chemical, and polymer markets, as well as the pharmaceutical and biotech markets. When combined with the latest compliant version of the iC Raman™ data acquisition software, the RAMANRXN2HYBRID analyzer meets the needs of both GLP and GMP governed areas within the pharmaceutical industry for both PAT and QbD applications.

The RAMANRXN2HYBRID analyzer provides the capability of several different Raman analyzers in a single system. Equally capable of being a transportable raw materials identification analyzer, a bench-top analyzer for methods development in the lab, reaction monitoring in the pilot plant, process control development in a manufacturing environment, or a dedicated quality control analyzer.

At the heart of the RAMANRXN2HYBRID analyzer is a unique analyzer self monitoring system to ensure the validity of each analysis. The analyzer is capable of self-calibration in extreme environments and utilizes self-diagnostics and spectral correction methods when system calibration is unnecessary. The analyzer's precision is essential for robust chemometric analyses and calibration transfer between analyzers.

Versatility was a key goal when developing the feature set for the RAMANRXN2HYBRID analyzer. Millimeter to micron sampling versatility is accomplished by coupling the RAMANRXN2HYBRID analyzer with either the MR Probe or the PhAT probe heads for non-contact or direct insertion sampling. Standard on all RAMANRXN2C™ models and available as an option for the RAMANRXN2HYBRID analyzer, is an ergonomic trolley including built-in probe and optic storage, a routine-analysis sample compartment, fiber storage, and the analyzer control system.

For in situ reaction analysis the RAMANRXN2HYBRID analyzer is capable of using either the MR Probe for laboratory measurements or the Pilot-E process probe for pilot-scale measurements from 100 to 10,000 gallons.

For formulations development, sampling versatility is accomplished using a fiber-optically coupled PhAT probe heads. Fiber-optic flexibility provides for simple flexible installation to various unit operations and a variety of manufacturing equipment. Both insertion and non-contact sampling options are available for the PhAT probe heads to enhance sampling flexibility. A special probe interface is available for in situ tablet coating applications.


MR Probe-based Reaction Analysis

  • in situ reaction monitoring
  • Reaction pathway understanding
  • Yield optimization
  • API development
  • Crystallization / form identification
  • Grignard reagent monitoring
  • Heterogeneous matrices
  • Hydrogenations
  • Bioprocesses 
  • Residual monomer analysis
  • Polymerization
  • Substitution / isomerization
  • Organometallic chemistry
  • Sensitive to organics and inorganics
  • Applicable to water-based chemistries


PhAT-based Formulation Studies

  • Analyze powders, slurries, flakes, plaques, gels, or liquids
  • PAT - R&D, primary, secondary or QA / QC
  • API polymorphic form and stability
  • API hydrate, solvate, or salt formation
  • API co-crystal formation
  • Unit operations; blending, granulation, milling, and drying
  • Process induced transformations during unit operations
  • Tablet coating and thickness
  • Tablet API form, content, and stability
  • Low doseage tablets (polymorph and degradants)
  • Amorphous content
  • Lyophilization
  • Hot melt-extrusion
  • PAC - polymers and catalysts


Analyzer Features

  • High performance spectroscopy
  • Representative mm scale measurements
  • in situ reaction sampling
  • Non-destructive measurements



  • Transport option
  • Laboratory optics and probe heads
  • Pilot plant compatible probes
  • Sampling compartment

iC Raman™ 3.0

  • 21 CFR Part 11 Compatible Data Acquisition
  • Wizard driven, easy-to-use application
  • Analyzer set-up and control
  • Experiment templates
  • Enhanced experiment phases
  • ConcIRT™ option
  • Treading, qualitative, and quantitative analysis modes

Precision, Stability, Methods Transfer

  • Better than 0.1 cm-1 long term precision
  • Cal-Check™ – system verification
  • Auto-Cal™ for analyzer calibration
  • NIST-traceable intensity calibration protocol – calibration from the sample to the detector
  • Demonstrated calibration transfer: Plant-to-plant, country-to-country
Video: Granulation Example

Product Material
RamanRxn2 Hybrid™ Analyzer
Product Flyer

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PhAT Probe for Solids Analysis
Product Flyer

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Current Trends in Polymer Raman Spectroscopy: Quality, Efficiency, and Safety

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