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Raman Spectroscopy

Raman Analyzers
RAMANRXN2™ Analyzer

The RAMANRXN2™ analyzer is targeted to drug discovery and early process optimization customers. In these regimes, multiple parallel small-scale reactors (10-100 mL) are often used to monitor, analyze, and optimize the reaction chemistry. The ability to simultaneously follow several different potential reaction pathways can significantly speed up early process development and remove bottlenecks in the optimization pipeline. The multichannel RAMANRXN2™ analyzer meets and solves this need.

Raman spectroscopy provides the chemical specificity of mid-IR spectroscopy and the sampling simplicity of a near-IR analyzer. By operating in the visible spectral region, Raman spectroscopy allows vibrational spectra to be collected in situ, using fiber-coupled probe heads, without sample purging, and without the use of exotic sampling devices. The RAMANRXN2 analyzer utilizes fiber-coupled probe optic technology for in situ reaction monitoring.

The RAMANRXN SYSTEMS™ suite of analyzers is based on advanced and innovative technologies that provide distinct advantages over traditional instrumentation. The HoloPlex™ advantage, standard in all RAMANRXN2 analyzers, yields both full spectral coverage and high spectral resolution simultaneously for improved qualitative and quantitative analysis. Analysis is fast because the entire Raman spectrum is measured simultaneously, which translates into real-time data collection for reaction analysis and monitoring.


Why Raman?

  • Fast, non-contact measurements
  • Sharp spectral peaks for qualitative and quantitative analysis
  • Univariate or multivariate comparative analysis methods
  • Chemical specificity of mid-IR with in situ analysis
  • Easy sampling of solids, liquids, slurries, and emulsions

Analyzer Features

  • Multiple sampling points
  • 1/4-inch-diameter immersion optic
  • 1/2-inch-diameter immersion optic options
  • Advanced self-calibration protocols
  • Real-time data acquisition applications
  • Crystallization studies
  • Hydrogenations
  • Catalysis investigations
  • Polymorphic form ID
  • Emulsion polymerizations

Advantages of Raman Spectroscopy...


RAMANRXN2™ Analyzer
  • Monitor up to four channels with simultaneous full-spectral coverage
  • Standard NIR laser excitation to maximize sample compatibility
  • Available in programmable sequential monitoring format
  • Compatible with process optics, enabling one analyzer type to be used from the discovery to the production phase
  • Portable enclosure and fiber optic sampling interface allows the analyzer to be used in multiple locations

MR Probe
  • Small probe construction (1/4-inch diameter, 6-inch, immersible) allows interface to standard glass reactors without an obstructive supporting gantry
  • Compatible with standard reactor glass vessels
  • Modular probe design allows the probe head to be upgraded with longer optical fibers and different immersion optics
Product Material
RamanRxn2™ Multi-channel Analyzer
Product Flyer

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Raman-Based Endpoint Detection of a Heterogeneous Etherification Reaction
Raman Application Note

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Monitoring Emulsion Polymerization by Raman Spectroscopy: An Executive Summary

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