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Raman Spectroscopy
Raman
Technical Resources
Raman Webinars
Kaiser hosts a series of webinars that center around Raman Spectroscopy and the industry. Register for our upcoming webinar, view previous archives, or mark your calendar for one of our upcoming topics of interest.
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| Single In Situ Probe Continuously Measures Multiple Bioprocess Components, Thereby Enabling Improved Bioprocess Management |
Date: June 20, 2013
Time: 10:00 AM EDT
(4:00 PM Central European Summer Time)
Location: Your Office
Duration: 45 Minutes
More: Space is limited!
Presenter: Tara L. Barreira
Scientist, Bioprocess Research and Development, Pfizer, Inc Register Now
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Description:
At our site we have integrated two Kaiser Raman systems into the Pilot Plant scale bioreactors to investigate their performance and validate methods for measuring glucose, lactate, and other process metabolites in real time. In conjunction with a preferred vendor, an application and technology assessment was performed using a combination of published literature, process knowledge, and technical expertise. A series of candidates for assessment were identified.
At our facility the bioreactors are fitted with an aseptic automated sampling (AAS) valve to deliver offline metabolite analysis at regularly scheduled intervals throughout the duration of the batches, enabling 24 hour sampling and more than doubling the amount of comparative samples that are collected. Successful data collection and nutrient determination from the Kaiser Raman enables real time quantification of metabolites and the ability to control nutrient feeds through automated feedback loops. Additional studies to examine protein concentration in downstream processing and correlate data to in process upstream measurements are also expected.
During the webinar, I will provide a brief overview of the biologics production process, and discuss the feasibility assessment of both NIR and Raman for metabolite quantification. This includes models based on inline and offline data as well as the development of control strategies. Lastly, the development of real time protein quantification from bioreactor process samples will be discussed. |
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Webinar Archive
| 2013-05-09 |
Topic: Raman Spectroscopy for Real Time Analysis in Pharmaceutical Manufacturing
Presenter: Dr. Dimuthu Jayawickrama
- Senior Research Investigator, Analytical and Bioanalytical Development Department at
Bristol Myers Squibb
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| 2013-04-11 |
Topic: Validating Transcutaneous Raman Spectroscopy in Human Subjects
Presenter: Dr. Francis Esmonde-White
- Research Area Specialist Lead
- Department of Chemistry, University of Michigan
Request a Viewable Link |
| 2013-03-28 |
Topic: Raman Testing of Amorphous Silicates and Zeolites
Presenter: Dr. Istvan Halasz - Principal Chemist and Special Analytical Group Supervisor,
PQ Corporation
Request a Viewable Link |
| 2013-01-10 |
Topic: Monitoring Emulsion Polymerization Using Raman Spectroscopy
Presenter: Dr. Serena Stephenson - The Dow Chemical Company
Request a Viewable Link |
| 2012-06-28 |
Topic: Kaiser Raman: The Ultimate in Sampling Flexibility for Solids, Liquids, and Gases
Presenter: Dr. Sean Gilliam, Product Specialist, Kaiser Optical Systems
Request a Viewable Link |
| 2012-04-05 |
Topic: Application of Raman Spectroscopy for Process Control and Understanding in the Pharmaceutical Industry
Part One: Lab and Plant Applications
Presenter: Dr. John M. Wasylyk, Principal Scientist at Bristol-Myers Squibb Company
Request a Viewable Link |
| 2011-10-20 |
Topic: Raman Spectroscopy for In-line Monitoring of Pharmaceutical Hot-melt Extrusion Processes
Presenter: Dr. Thomas De Beer, Professor of Process Analytical Technology at the University of Ghent
Request a Viewable Link |
| 2011-06-23 |
Topic: Non-invasive Raman Analysis of Pharmaceutical Tablets and Powders
Presenter: Dr. David Littlejohn
- Professor and Associate Deputy Principal for Research at the University of Strathclyde
Request a Viewable Link |
| 2011-05-19 |
Topic: Spatially Off-set and Transmission Raman Spectroscopy, Imaging, and Tomography in Light Scattering Media
Presenter: Dr. Matthew Schulmerich
- Department of Defense Postdoctoral Fellow - University of Illinois
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| 2011-04-14 |
Topic: Raman Spectroscopic Fingerprint of Intermediates in Biotechnological Reactions - A Multimodal Spectroscopic Approach
Presenter: Dr. Rudolf W. Kessler
- Professor of Chemistry at Reutlingen University, Germany
- Head of the Process Analysis group at the Reutlingen Research Institute
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| 2011-03-24 |
Topic: Dispersive Raman Spectroscopy - A Powerful Tool Within the Development of Crystallization and Drying Processes for Pharmaceutical Compounds
Presenter: Dr. Martin Feth - Head of Laboratory in Chemical Development and Physical Quality of API at Sanofi-Aventis Deutschland GmbH
Request a Viewable Link |
| 2011-02-17 |
Topic: Monitoring Homogeneity Using Raman Spectroscopy in Inhalation Products
Presenter: Dr. Chanda Yonzon - Associate Principal Scientist, Merck & Co.
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| 2010-11-30 |
Topic: Transmission Raman Spectroscopy: Where Are We Looking, What Are We Seeing?
Presenter: Dr. Neil Everall - Company Research Associate, Intertek MSG
Request a Viewable Link |
| 2010-09-30 |
Topic: Real Time Release Testing of Pharmaceutical Drug Products: How Does Raman Measure Up?
Presenter: Dr. Manoharan Ramasamy - Principal Scientist and PAT Leader, Merck & Co, Inc
Request a Viewable Link |
| 2010-09-09 |
Topic: Petrochemical Applications of In-Situ Gas-Phase Raman Spectroscopy
Presenter: Dr. George Vickers - Research Associate, BP America
Request a Viewable Link |
| 2010-07-15 |
Topic: Discovery and Characterization of Tetraalkylammonium Polybromides with Raman Spectroscopy
Presenter: Dr. Shawn Chen - Senior Chemist, Dow Chemical
Request a Viewable Link |
| 2010-06-24 |
Topic: Application of Raman for Improved Biofuel Processing
Presenter: Dr. Brian Marquardt - Applied Physics Laboratory, University of Washington
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| 2010-05-20 |
Topic: Multichannel Reaction Monitoring with iC Raman™ 4.1
Presenter: Maryann Cuellar - Product Specialist
Kaiser Optical Systems, Inc.
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| 2010-04-22 |
Topic: Closed Loop Control of Titanium Dioxide Production Using Process Raman Spectroscopy
Presenter: Dr. Neil Everall - Company Research Associate, Intertek MSG
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| 2010-03-25 |
Topic: The Role of Raman Microscopy in Polymorph Screening
Presenter: Sarah Vallance - Research Scientist, Solid Form Sciences at GlaxoSmithKline
Request a Viewable Link |
| 2010-03-11 |
Topic: Application of Raman Spectroscopy to Solid-state Characterization During Early Drug Development
Presenter: Dr. Sachin Lohani, Solid-state Characterization Expert, Merck & Company
Request a Viewable Link |
| 2010-02-25 |
Topic: Polarized Raman Scattering: A Powerful Tool for Characterization of Orientation
Presenter: Dr. Bruce Chase Research Professor, University of Delaware
CTO of Pair Technologies LLC
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| 2010-01-28 |
Topic: Using iC Raman™ for Process Development
Presenter: Greg Gervasio - Process Analytical Technology Professional Engineer at GlaxoSmithKline
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| 2010-01-14 |
Topic: Concomitant Nucleation of Polymorphs on Engineered Surfaces
Presenter: Dr. Allan Myerson
Professor of Engineering in the Department of Chemical and Biological Engineering at the Illinois Institute of Technology (IIT)
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| 2009-12-03 |
Topic: Application of Raman Spectroscopy for Pharmaceutical Process Understanding
Presenter: Dr. Saly Romero-Torres , Principal PAT Scientist at Pfizer
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| 2009-11-24 |
Topic: Vibrational Spectroscopy and Microspectroscopic Imaging: Introduction and Applications to Skin Pharmacology and Wound Healing
Presenter: Dr. Richard Mendelsohn, Professor of Chemistry - Rutgers University
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| 2009-10-29 |
Topic: Quantitative Gas-phase Analysis Using the Kaiser AirHead™ Probe
Presenter: Dr. Pat Wiegand, Kaiser Product Specialist
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| 2009-10-15 |
Topic: Monitoring Zeolite Syntheses Using In-Situ Raman Spectroscopy
Presenter: Dr. Tom Mezza
Sr. Principle Research Scientist, UOP LLC
Request a Viewable Link |
| 2009-09-17 |
Topic: Kaiser RamanRXN2™ 1000 Webinar
Presenter: Maryann Cuellar Kaiser Product Specialist
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| 2009-06-04 |
Topic: Non-invasive and Minimally Invasive Raman Spectroscopy of Musculo-skeletal Tissue: A Multidisciplinary Approach
Presenter: Michael D. Morris - Professor of Chemistry, University of Michigan
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| 2009-05-07 |
Topic: Raman Spectroscopy as a PAT Tool for Coating
Presenter: Dr. Peter Kleinebudde
Professor at the Institute of Pharmaceutics and Biopharmaceutics
Heinrich-Heine-University, Duesseldorf
Request a Viewable Link |
| 2009-04-23 |
Topic: Using in-situ Raman for Improved Process Understanding in Development of a Crystallization Process
Presenter: Dr. Jun Chen, Principal Scientist, GlaxoSmithKline
Request a Viewable Link |
| 2009-04-02 |
Topic: Analytical Data: the Good, the Bad, and the Ugly
Presenter: Dr. Pat Wiegand, Kaiser Product Specialist.
Request a Viewable Link |
| 2009-02-19 |
Topic: Transmission Raman Spectroscopy for Quantitative Analysis of Pharmaceutical Solids
Presenter: Anders Sparén, Associate Principal Scientist AstraZeneca
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| 2009-01-29 |
Topic: Petrochemical Gas/Liquid Analyses - A New Frontier for On-line Raman Spectroscopy
Presenter: Dr. Peter van Vuuren
Request a Viewable Link |
| 2009-01-15 |
Topic: Introduction to iC Raman™ V3.0
Presenter: Maryann Cuellar, Product Specialist, Kaiser Optical Systems
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| 2008-12-09 |
Topic: Application of Dispersive Raman Spectroscopy During Drug Development
Presenter: Dr. Brigida Allieri
Principal Scientist, GlaxoSmithKline
Request a Viewable Link |
| 2008-11-12 |
Topic: Kaiser Raman WorkStation™ with Dr. Sean Gilliam
Presenter: Dr. Sean Gilliam, Kaiser Product Specialist
Request a Viewable Link |
| 2008-10-23 |
Topic: Mechanistic Basis for Effective Cocrystal Screening Methods
Presenter: Dr. Nair Rodriguez-Hornedo, Associate Professor of Pharmaceutical Sciences, University of Michigan
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| 2008-07-10 |
Topic: Raman Monitoring in the Petrochemical Industry
Presenter: Dr. Alan D. Eastman, Process Analytical Chemistry Consultant, Eastman Associates LLC
Request a Viewable Link |
| 2008-06-26 |
Topic: Quantitative Process Raman
Presenter: Dr. Brian J. Marquardt, Applied Physics Labs, University of Washington
Request a Viewable Link |
| 2008-03-27 |
Topic: Kaiser Raman WorkStation™ with Dr. Mark Kemper
Presenter: Mark Kemper, International Sales Manager, Kaiser
Request a Viewable Link |
| 2008-01-17 |
Topic: Kaiser iC Raman™ V2.0
Presenter: Maryann Cuellar, Product Specialist, Kaiser
Request a Viewable Link |
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