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Raman Spectroscopy
Raman
Technical Resources
Raman Webinars
Kaiser hosts a series of webinars that center around Raman Spectroscopy and the industry. Register for our upcoming webinar, view previous archives, or mark your calendar for one of our upcoming topics of interest.
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| Application of Raman Spectroscopy to Solid-state Characterization During Early Drug Development |
Date: March 11, 2010
Time: 10:00 AM EDT
Location: Your Office
Duration: 45 Minutes
More: Space is limited!
Presenter: Dr. Sachin Lohani, Solid-state Characterization Expert, Merck & Company Register Now
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Description:
Raman spectroscopy generally serves as a secondary technique for solid-sate characterization of pharmaceuticals in early stages of drug development. However, in certain cases this technique is of primary importance. Case studies will illustrate practical scenarios in which this technique is preferred over conventional solid-state characterization techniques, such as x-ray powder diffraction (XRPD).
Case Study 1: Raman spectroscopy was used to investigate the disproportionation of the hydrochloride salt of a free base. Due to the isostructural nature of their crystalline lattice, XRPD patterns could not be used to differentiate between the hydrochloride salt and the free base hydrate using X-ray diffraction. However the Raman spectrum of the two forms showed clear differences. This enabled in-situ monitoring by Raman spectroscopy which provided key information on the viability of the hydrochloride salt for further development.
Case Study 2: Hydrate formation for compound B in various binary mixtures of organic solvent and water was monitored in-situ using dispersive Raman spectroscopy. The data was used to identify process conditions under which the desired phase was thermodynamically stable and could be scaled up without risk of generating the undesired phase.
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| The Role of Raman Spectroscopy in Polymorph Screening |
Date: March 25, 2010
Time: 10:00 AM EDT
Location: Your Office
Duration: 45 Minutes
More: Space is limited!
Presenter: Sarah Vallance - Research Scientist, Solid Form Sciences at GlaxoSmithKline Register Now
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Description:
Polymorphism is the ability of a molecule to exist in more than one crystalline form. These solid-state forms may exhibit variation in, for example, colour, stability, processability, dissolution and bioavailability, ranging from the subtle to the severe. It is for this reason that an understanding of the solid-state behaviour of a drug molecule, including the identification of all possible forms, and thorough characterisation of the observed forms is of prime importance within the pharmaceutical industry.
An in-depth understanding of the polymorph landscape of a drug candidate relies on the development and implementation of a reliable screening protocol.
During the early phases of drug development there is high attrition of drug candidates therefore screening efforts are more focussed on identifying the most stable polymorph and any process-relevant solvates or hydrates. As a drug progresses, however, attrition rates become lower and screening is more thorough, with the aim being to develop a comprehensive understanding of the polymorph landscape.
Polymorph screening at any stage requires high-throughput analysis of a large number of samples with minimal sample preparation. Thus Raman microscopy provides the ideal analytical solution.
This presentation will describe a particular case study, in which Raman microscopy was fully utilized to characterise a number of different anhydrous, hydrated and solvated forms. The study enabled selection of the most suitable solid-state form for further development as well as mitigating the risk of hydrate formation during primary and secondary processing.
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Webinar Archive
| 2010-02-25 |
Topic: Polarized Raman Scattering: A Powerful Tool for Characterization of Orientation
Presenter: Dr. Bruce Chase Research Professor, University of Delaware
CTO of Pair Technologies LLC
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| 2010-01-28 |
Topic: Using iC Raman™ for Process Development
Presenter: Greg Gervasio - Process Analytical Technology Professional Engineer at GlaxoSmithKline
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| 2010-01-14 |
Topic: Concomitant Nucleation of Polymorphs on Engineered Surfaces
Presenter: Dr. Allan Myerson
Professor of Engineering in the Department of Chemical and Biological Engineering at the Illinois Institute of Technology (IIT)
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| 2009-12-03 |
Topic: Application of Raman Spectroscopy for Pharmaceutical Process Understanding
Presenter: Dr. Saly Romero-Torres , Principal PAT Scientist at Pfizer
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| 2009-11-24 |
Topic: Vibrational Spectroscopy and Microspectroscopic Imaging: Introduction and Applications to Skin Pharmacology and Wound Healing
Presenter: Dr. Richard Mendelsohn, Professor of Chemistry - Rutgers University
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| 2009-10-29 |
Topic: Quantitative Gas-phase Analysis Using the Kaiser AirHead™ Probe
Presenter: Dr. Pat Wiegand, Kaiser Product Specialist
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| 2009-10-15 |
Topic: Monitoring Zeolite Syntheses Using In-Situ Raman Spectroscopy
Presenter: Dr. Tom Mezza
Sr. Principle Research Scientist, UOP LLC
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| 2009-09-17 |
Topic: Kaiser RamanRXN2™ 1000 Webinar
Presenter: Maryann Cuellar Kaiser Product Specialist
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| 2009-06-04 |
Topic: Non-invasive and Minimally Invasive Raman Spectroscopy of Musculo-skeletal Tissue: A Multidisciplinary Approach
Presenter: Michael D. Morris - Professor of Chemistry, University of Michigan
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| 2009-05-07 |
Topic: Raman Spectroscopy as a PAT Tool for Coating
Presenter: Dr. Peter Kleinebudde
Professor at the Institute of Pharmaceutics and Biopharmaceutics
Heinrich-Heine-University, Duesseldorf
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| 2009-04-23 |
Topic: Using in-situ Raman for Improved Process Understanding in Development of a Crystallization Process
Presenter: Dr. Jun Chen, Principal Scientist, GlaxoSmithKline
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| 2009-04-02 |
Topic: Analytical Data: the Good, the Bad, and the Ugly
Presenter: Dr. Pat Wiegand, Kaiser Product Specialist.
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| 2009-02-19 |
Topic: Transmission Raman Spectroscopy for Quantitative Analysis of Pharmaceutical Solids
Presenter: Anders Sparén, Associate Principal Scientist AstraZeneca
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| 2009-01-29 |
Topic: Petrochemical Gas/Liquid Analyses - A New Frontier for On-line Raman Spectroscopy
Presenter: Dr. Peter van Vuuren
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| 2009-01-15 |
Topic: Introduction to iC Raman™ V3.0
Presenter: Maryann Cuellar, Product Specialist, Kaiser Optical Systems
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| 2008-12-09 |
Topic: Application of Dispersive Raman Spectroscopy During Drug Development
Presenter: Dr. Brigida Allieri
Principal Scientist, GlaxoSmithKline
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| 2008-11-12 |
Topic: Kaiser Raman WorkStation™ with Dr. Sean Gilliam
Presenter: Dr. Sean Gilliam, Kaiser Product Specialist
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| 2008-10-23 |
Topic: Mechanistic Basis for Effective Cocrystal Screening Methods
Presenter: Dr. Nair Rodriguez-Hornedo, Associate Professor of Pharmaceutical Sciences, University of Michigan
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| 2008-07-10 |
Topic: Raman Monitoring in the Petrochemical Industry
Presenter: Dr. Alan D. Eastman, Process Analytical Chemistry Consultant, Eastman Associates LLC
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| 2008-06-26 |
Topic: Quantitative Process Raman
Presenter: Dr. Brian J. Marquardt, Applied Physics Labs, University of Washington
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| 2008-03-27 |
Topic: Kaiser Raman WorkStation™ with Dr. Mark Kemper
Presenter: Mark Kemper, International Sales Manager, Kaiser
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| 2008-01-17 |
Topic: Kaiser iC Raman™ V2.0
Presenter: Maryann Cuellar, Product Specialist, Kaiser
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