The newest member of the RAMANRXN SYSTEMS™ suite of Raman analyzers is the PhAT System.
The PhAT System has been designed to address the limitations of even the best traditional Raman system for quantitative analyses of solid-state chemistries including pharmaceutical, catalysts, polymers, and specialty chemicals.

The PhAT System has revolutionized solids sampling by elimination sample irreproducibility and focusing, by measuring a representative volume of sample, and by offering the benefits of non-destructive sampling using laser powers below the ANSI exposure limit for skin. Both insertion and non-contact sampling options are available to enhance sampling flexibility.

Raman data generated is high in information content and these peaks can often be interpreted in terms of individual chemical moieties, thus providing a fundamental insight into critical quality variable and attributes.

The PhAT System is built upon the already established technology of the RAMANRXN SYSTEMS™ widely regarded as setting the standard for Raman analyzers for reliability, stability, applicability, and productivity.

The standard for simplicity and reliability for Raman spectroscopic analysis of solids samples has been redefined with the PhAT System. The PhAT System is opening up new application areas to Raman analysis both in-situ and at-line.

Applications

• Analyze powders, slurries, flakes, plaques, gels, or liquids
• PAT - R&D, Primary, Secondary or QA/QC
• API polymorphic form and stability
• API hydrate, solvate or salt formation
• API co-cystal formation
• Unit operations; blending, granulation, milling, and drying
• Process induced transformations during operations
• Table! coating and thickness
• Tablet API form, content, and stability
• Low doseage tablets (polymorph and degradants)
• Lyophilization
• Hot melt-extrusion
• PAC - polymers and catalysts
  

• Representative mm scale measurement
• Reproducible sampling
  "Focus free" alignment
• Non-contact or insertion sampling
• Non-destructive measurement

Why Raman?

• Fast measurements
• Sharp spectral peaks for qualitative and quantitative analysis
• Univariate or multivariate prediction mode
  

"Raman Spectroscopy: A PATTool'for Quantitative Assessment of'Tablet Potency ", J. Johansson, J. Eriksson, S. Folestad, and B. Lagerholm, FACSS, 50S. Oct (2004) - AstraZeneca

"Raman Spectroscopy for Quantitative Monitoring of Solid Dosage Manufacturing Process ", S-Y. Chang, A. El-Hagrasy, W. Earlv, H. Guo, D. Li, S. Kotliari, S. Paruchuri, and V. Nesarikar, IFPAC, 1-142, Jan 13 (2005) - BMS

"Comparison of Techniques for In-line Monitoring using Raman Spectroscopy.", H Wikstrom, l.R. Lewis and L.S. Taylor, Appl. Spectrosc., 59, 934-941 (2005) - Purdue University

"Raman Spectroscopy for Quantitative Monitoring of Tablet Coating ", S-Y. Chang, A. El-Hagrasy, S. Paruchini, S. Kothari. D. Desai, and S. Kiang, FACSS, 92, Oct (2005) - BMS

"Quantitation of Polymorphs in Drug Products by Raman Spectrascopv ", F. LaPlant and X. Zhang, Am.Pharn.Rev.,8, 88-95 (2005)-Pfizer