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METTLER TOLEDO and Kaiser Launch Latest Software Version



Kaiser Optical Systems Inc. (Kaiser) and METTLER TOLEDO are pleased to announce the release of iC Raman™ V4.1 for select RamanRxn Systems™ RAMANRXN SYSTEMS™ and PhAT System analyzers.

iC Raman™ V4.1 is the third generation of the original iC Raman™ platform since its initial release in 2007. Both companies are established leaders in in situ analytical market segments and provide high quality innovative products and services to the Process Analytical community.

iC Raman™ 4.1 provides Raman users instrument configuration, data acquisition, and reaction analysis software for Kaiser’s Raman analyzers. Designed as a "quick-to-learn" application, even inexperienced users can be proficient on iC Raman™ 4.1 software - within minutes. iC Raman™ 4.1 provides a wizard-driven environment for rapid analyzer setup and data collection, leaving the chemist time to focus on chemistry. The iC platform provides powerful data acquisition and interpretation tools which allow users to quickly evaluate Raman data from Kaiser analyzers. This is achieved, in part, via new features including: comparison of live data with previous experiments and the ability to monitor multiple concurrent reactions (multichannel capable). “The ability to bring multiple analytical tools to bear on a single problem and exchange data between these tools should accelerate chemical development for many of our industrial users,” said Ian Lewis, marketing manager at Kaiser Optical Systems.

Building on the METTLER TOLEDO iC Software framework, the latest version of iC Raman™ allows for integration with METTLER TOLEDO Automatic Lab Reactors (ALR) through iControl RC1e™, iControl LabMax™, and iControl EasyMax™ software. In addition, iC Raman™ also integrates with, and allows data exchange between, iC Raman™ and METTLER TOLEDO iC IR™ and iC FBRM™ software.


Kaiser Announces the RAMANRXN21000 Raman Analyzer



Kaiser is pleased to announce the release of the RAMANRXN2 1000 Raman analyzer.

The RAMANRXN2 1000 analyzer provides the fluorescence rejection of a FT-Raman spectrometer but with the ease of fiber-optic interfacing of a dispersive Raman analyzer. Using 1000 nm excitation is a compromise between fluorescence rejection and detection sensitivity. For non-Raman spectroscopists the observation of any level of fluorescence background can lead to a desire to move to a different excitation wavelength. However it is often possible to remove the background during a data analysis step leaving a residual spectrum of high enough signal-to-noise ratio to allow quantitative analysis. While 785-nm excitation remains the most universal wavelength for petrochemical and pharmaceutical Raman applications, some applications for example early stage "dirty" crystallization, biofuels, polyurethanes, heavy hydrocarbons, and some colorants / pigments exhibit fluorescence too intense to allow the application to be addressed with 785-nm excitation. For these applications the RAMANRXN2 1000 analyzer provides an effective route for in situ monitoring.

In order to optimize performance in this wavelength range and bring this analyzer to market it was necessary to incorporate developments in

  • Diode lasers
  • InGaAs array detectors
  • Refractive axial transmissive spectrographs
  • Reaction analysis software

in order to obtain maximize detected Raman signals.

"The RAMANRXN2 1000 Raman analyzer fills a niche for Raman analyzers for application where fluorescence cannot be overcome using 785-nm excitation. In certain cases a Raman method had to be employed off-line because the only available instrumentation capable of overcoming sample fluorescence was an FT-Raman spectrometer. With the introduction of the RAMANRXN2 1000 Raman analyzer these Raman measurements can be made on-line allowing users the potential to develop process control methodologies rather than end-product testing," says Ian Lewis, Marketing Manager at Kaiser.

This analyzer is offered with either iC Raman™ 4.1 for reaction development and understanding, or synTQ-Lite for process monitoring and control where compliance to 21 CFR Part 11 and interface to data historians are required.


Kaiser Announces the RAMAN WORKSTATION™ Raman Analyzer



Kaiser is pleased to announce the release of a new generation RAMAN WORKSTATION™ Raman analyzer.

Formulation development remains a critical step in the development of a new drug product. Each step represents a risk to product quality as each step exposes the active pharmaceutical ingredient to potential change and / or dilution. In order to evaluate process induced transformations in situ, Kaiser developed PhAT technology in 2005. In addition to in situ testing it is also possible to use Raman for unit doseage confirmation by using transmission Raman approaches to evaluate content uniformity. While transmission Raman has the potential to provide whole tablet quantitation it cannot provide detailed information on the product surface or indications of clumping of the active pharmaceutical ingredient. In order to obtain this type of information a Raman microscope is typically used. Thus in order to obtain detailed information on the formulation process it has been necessary for a company to invest in and use two different types of Raman analyzers.

The RAMAN WORKSTATION™ Raman analyzer addresses both these needs in a single analyzer. Raman images from the surface and the bulk can be provided at either low or high spatial resolution without removing the tablet. In transmission modes the RAMAN WORKSTATION™ Raman analyzer can be used to evaluate tablet’s or capsule’s content uniformity.

Utilizing a RAMAN WORKSTATION™ Raman analyzer a formulation's critical quality attributes during the formulation development phase can be determined. This information can be fed back to the manufacturing team to ensure an optimized deployment of an in situ RAMAN WORKSTATIONPhAT-capable analyzer in order to monitor and control critical parameters, thus ensuring optimized product quality while meeting the goals of the Quality by Design (QbD) initiative.

The RAMAN WORKSTATION™ Raman analyzer meets the needs of the pharmaceutical and solids catalyst markets where solids formulations development is critical. The combination of the capabilities of a wide area Raman analyzer and a Raman microscope make the analyzer attractive in term of both analyzer ROI and analyst time.




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