The term “biotech” encompasses a varied field of chemistries and chemical processes, and thus presents several unique applications needs. Raman is well suited to certain biotech processes as it is non-destructive in nature, can sample reactions in situ, and is compatible with aqueous chemistries.
Raman has been successfully applied to protein studies, during protein crystal growth, and for drug protein screening experiments.
Other applications for cellular processes include nutriment level for tracking for reaction monitoring, yield optimization, control purposes, and biomarker identification.
Biotech processes present challenges to Raman analysis, including opaque, highly scattering samples, probe clean-ability (for in situ measurements), and significant backgrounds. However the appropriate choice of excitation wavelength, probe design, and analysis software can allow these challenging applications to be accomplished.
Contact a Kaiser Expert to discuss your applications needs.
Further information on biotech Raman applications can be found in Handbook of Raman Spectroscopy: From Laboratory to Process Line by Ian R. Lewis and Howell G. M. Edwards, Marcel Dekker, New York, New York (2001)