Kaiser Optical Systems
Home About Us Products News Trade Shows Careers Contact Us

The PhAT System Raman analyzer is a variant of the RAMANRXN1™ analyzer specifically designed to address the limitations of even the best traditional Raman system for quantitative analyses of solid-state chemistries including pharmaceutical, catalysts, polymers, and specialty chemicals.

The application of PhAT technology has revolutionized solids sampling by eliminating sample irreproducibility and focusing, by measuring a representative volume of sample, and by offering the benefits of non-destructive sampling using laser powers below the ANSI exposure limit for skin.

Raman data generated is high in information content and these peaks can often be interpreted in terms of individual chemical moieties, thus providing a fundamental insight into critical quality variable and attributes. The PhAT System is built upon the already established technology of the RAMANRXN SYSTEMS™ suite of Raman analyzers widely regarded as setting the standard for Raman analyzers for reliability, stability, applicability, and productivity.

Sampling versatility to various unit operations and a variety of manufacturing equipment is accomplished using a fiber-optically coupled PhAT probe head. Both insertion and non-contact sampling options are available for the PhAT probe head to enhance sampling flexibility. A special probe interface is available for in situ tablet coating applications.

The PhAT System Raman analyzer was designed for formulations development in the laboratory. For production in a manufacturing environment where cleanability is required for both the PhAT probe head and the analyzer, the RAMANRXN3PhAT analyzer is available.

The advent of PhAT technology has redefined the standard for simplicity and reliability for Raman spectroscopic analysis of solids samples. The use of PhAT technology is opening up new areas to Raman analysis both in situ and at-line including solid-state chemistries applications and with the pharmaceutical, catalysts, polymers, and specialty chemicals industries.



  • Analyze powders, slurries, flakes, plaques, gels, or liquids
  • PAT - R&D, primary, secondary or QA/QC
  • API polymorphic form and stability
  • API hydrate, solvate, or salt formation
  • API co-crystal formation
  • Unit operations; blending, granulation, milling, and drying
  • Process induced transformations during unit operations
  • Tablet coating and thickness
  • Tablet API form, content, and stability
  • Low doseage tablets (polymorph and degradants)
  • Lyophilization
  • Hot melt-extrusion
  • PAC - polymers and catalysts


Advantages of Raman Spectroscopy...
Video: Granulation Example

Analyzer Features

  • Representative mm scale measurement
  • Reproducible sampling
  • “Focus free” alignment
  • Non-contact or insertion sampling
  • Non-destructive measurement
  • 21 CFR Part 11 compatible software option

Why Raman?

  • Fast measurements
  • Sharp spectral peaks for qualitative and quantitative analysis
  • Univariate or multivariate prediction mode

Select Customer Publications

"Raman Spectroscopy: A PAT Tool for Quantitative Assessment of Tablet Potency", J. Johansson, J. Eriksson, S. Folestad, and B. Lagerholm, FACSS, 50S. Oct (2004) - AstraZeneca

"Raman Spectroscopy for Quantitative Monitoring of Solid Dosage Manufacturing Process", S-Y. Chang, A. El-Hagrasy, W. Earlv, H. Guo, D. Li, S. Kotliari, S. Paruchuri, and V. Nesarikar, IFPAC, 1-142, Jan 13 (2005) - BMS

"Comparison of Techniques for In-line Monitoring using Raman Spectroscopy.", H Wikstrom, l.R. Lewis and L.S. Taylor, Appl. Spectrosc., 59, 934-941 (2005) - Purdue University

"Raman Spectroscopy for Quantitative Monitoring of Tablet Coating", S-Y. Chang, A. El-Hagrasy, S. Paruchini, S. Kothari. D. Desai, and S. Kiang, FACSS, 92, Oct (2005) - BMS

"Quantitation of Polymorphs in Drug Products by Raman Spectroscopy", F. LaPlant and X. Zhang, Am.Pharn.Rev.,8, 88-95 (2005) - Pfizer



Product Material
PhAT System
Product Flyer

Warning: Invalid argument supplied for foreach() in /home/kosi4wsa2015/public_html/inc/display_fns.php on line 6
PhAT Probe for Solids Analysis
Product Flyer

Warning: Invalid argument supplied for foreach() in /home/kosi4wsa2015/public_html/inc/display_fns.php on line 6


Home  •  About Us  •  Products  •  Media Room  •  Trade Shows  •  Careers  •  Contact Us  •  Sitemap
©2018 Kaiser Optical Systems, Inc., All Rights Reserved.   Legal Notice